Susan Hawk (Food Science and Nutrition), David Gee (Food Science and Nutrition)
Lactose intolerance disproportionately affects racial minority groups in the United States, adversely impacting the incidence of calcium deficiency and low bone mineral density in these populations. The nutritional quality of lactose-containing food products incentivizes the investigation of long-term treatment options for lactose intolerance. Modifying the gut microbiome to increase the quantity of lactose-fermenting bacteria in the intestines is a promising avenue of treatment that merits investigation. This modification is typically done via consumption of probiotics, prebiotics, or synbiotics in various forms. This systematic review examined 23 studies measuring outcomes of lactose intolerance in subjects given probiotic, prebiotic, or synbiotic treatments. Bacterial strains with the greatest degree of evidence for symptom and/or hydrogen breath test score reduction were Bifidobacterium longum and Streptococcus thermophilus. Also, the novel galacto-oligosaccharide RP-G28 prebiotic may attenuate adverse outcomes of lactose intolerance.
Keywords: Probiotic, Lactose Intolerance, Lactase Deficiency