Chemistry

Sustainable Synthesis Medicinally Important Large, Nitrogen-Containing Cyclic Compounds

Author(s) Jane Eichwald, Jayme Zesiger Faculty Mentor(s) Timothy Beng (Chemistry) Abstract Macrocycles are large, flexible cyclic molecules containing 11+ atoms. They are present in pharmaceuticals such as Rhazinilam (anticancer) and in naturally-derived molecules. However, their large size makes them fragile and difficult to create. Meanwhile,… Read More »Sustainable Synthesis Medicinally Important Large, Nitrogen-Containing Cyclic Compounds

Investigation of Dalea nana Flavonoids with the Potential for Activity Toward ABC Transporters of Genetically Modified Fungi

Author(s) Caroline Cruz Faculty Mentor(s) Gil Belofsky (Chemistry) Abstract The flowering plant Dalea nana Torr. ex A. Gray, native to Arizona, has never been explored for its chemical content. In our ongoing research of the chemistry of Dalea spp., we explore the potential for medicinal… Read More »Investigation of Dalea nana Flavonoids with the Potential for Activity Toward ABC Transporters of Genetically Modified Fungi

Construction of Conformationally Restricted Bicyclic Lactam-Lactones by sp3 C-H Oxygenation

Author(s) Victoria Shearer Faculty Mentor(s) Timothy Beng (Chemistry) Abstract Climate change is a daunting predicament the world has found itself in, leading to an increase in green chemistry. A green chemistry technique that utilizes C-H bond activation is desirable. Due to this, a sustainable, cost-effective,… Read More »Construction of Conformationally Restricted Bicyclic Lactam-Lactones by sp3 C-H Oxygenation

Green Synthesis of Pharmaceutically Pertinent Bicyclic Pyrrolidines using the Castagnoli-Cushman Reaction

Author(s) Claire Borg, Michael Moilanen Faculty Mentor(s) Academic Service Learning in Public Health Abstract The synthesis of nitrogen-containing cyclic compounds (commonly known as azaheterocycles or N-heterocycles) has constantly been of importance to pharmaceutical companies given that they have great beneficial biological activities. One of these… Read More »Green Synthesis of Pharmaceutically Pertinent Bicyclic Pyrrolidines using the Castagnoli-Cushman Reaction

Stӧber Process Variation Via a Coacervate Environment

Author(s) Rory McFarland, Matthew Rimpler Faculty Mentor(s) Dion Rivera (Chemistry) Abstract When introduced into an aqueous solution of potassium bromide within a well-defined concentration range, poly(diallyl ammonium chloride) (PDADMAC) and poly(sodium-4-styrene sulfonate) (PSS) polyelectrolytes can form a biphasic state known as a complex coacervate. The… Read More »Stӧber Process Variation Via a Coacervate Environment

Charting the Chemical Reactivity Space of Castagnoli-Cushman-Derived N-Heterocyclic Sulfones

Author(s) Jorge Garcia Faculty Mentor(s) Timothy Beng (Chemistry) Abstract N-heterocyclic sulfones are present in many pharmaceuticals, including antityrpanosomal drug Nifurtimox. There is therefore an increasing demand for methodologies that create N-heterocyclic sulfones. This is all the more necessary since drug-resistance issues continue to persist, and… Read More »Charting the Chemical Reactivity Space of Castagnoli-Cushman-Derived N-Heterocyclic Sulfones

Towards the Synthesis of Novel Boronates as Potential HIV-1 Protease Inhibitors

Author(s) Aleksey Lanin, Alexandria Glebe Faculty Mentor(s) Levente Fabry-Asztalos (Chemistry) Abstract Human Immunodeficiency Virus (HIV) is a transmissible pathogen that negatively impacts nearly 38 million lives globally. The virus attacks the host’s white blood (CD4) cells to successfully replicate viral genetic information. Retroviral aspartyl protease… Read More »Towards the Synthesis of Novel Boronates as Potential HIV-1 Protease Inhibitors