Computational Model for Growth Cone Motility Guidance Using Laser-Induced Electromagnetic Gradients

Student: Desiree Ramirez

Mentor: Erin Craig

Abstract

Many neurodegenerative diseases are caused by the disruption of processes vital to neurons and their surrounding networks, including communication, metabolism, and repair. Damage to nerve axons can result in loss of nerve function and cell death. In order to repair these neurons in vivo, the ability to regenerate the damaged axons and then guide the axons along paths that will result in functional connections is necessary. This requires the development of noninvasive, highly efficient tools to guide the movement of a structure called the growth cone, which facilitates axon growth and guidance. Using purely optical repulsive and attractive guidance techniques with low power and near infrared light provides a noninvasive and efficient tool to repair neurons and restore their vital processes. While the experimental data demonstrates the ability of optical cues to guide growth cone motility, computational models are needed to provide new insights and to suggest which variables are most important in future experiments. Computational models lead to a new and better understanding of the system being investigated. The goal of this project is to create a computational model that complements published experimental data, providing a novel understanding of growth cone motility and how it can be used in the treatment of neurodegenerative diseases. Initial simulations using custom Matlab code demonstrate that an optical guidance cue can induce growth cone turning.

Presentation

5 thoughts on “Computational Model for Growth Cone Motility Guidance Using Laser-Induced Electromagnetic Gradients”

  1. Michael Braunstein

    If I understand correctly, your modeling is only in two dimensions. What would you do to extend your modeling approach to three dimensions?

  2. Michael Braunstein

    I wonder if characterizing the potential use of laser radiation for treating neurons is perhaps overselling it a bit. Means for accessing neurons for treatment with laser radiation seems to me as though it would still need to be invasive – maybe minimally invasive, but still invasive. (This is one of my things: I have concerns for backlash against science by the public due to “overselling” what science will be able to do; I think using “the science voice” (provisional, precise, and dispassionate) is more appropriate.)

    1. Hi Dr. Braunstein,
      Thank you for your comment! I keep it in mind as my project progresses, as I know it is hard (especially now) to keep the public’s trust in science.

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